| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate.
- Also known as: Dizocilpine hydrogen maleate
- CAS number: 77086-22-7
- Molecular formula: C20H19NO4.
- Purity: >99% (HPLC)
- Concentration: 0.01-10 µM.
- Form: Lyophilized powder.
- Solubility: Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
- Reconstitution: Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: NMDA receptors
- Source: Synthetic
- Activity: (+)-MK 801 maleate is a potent, selective and non-competitive NMDA receptor antagonist with an IC50 of 0.01 μM1.
- Alternative names: Dizocilpine hydrogen maleate
Scientific background
MK-801 maleate is a non competitive, high affinity, open channel blocker of the N-methyl-D-aspartate (NMDA) receptors. MK-801 blocks NMDA-induced currents in a voltage-dependent manner, preventing the influx of calcium ions through the channel. This compound is being used as a pharmacological tool to explore NMDA receptor function.The drug exists in two isomers (+) and (-) and displays several biological properties such as anticonvulsant and anesthetic. MK-801 is not used clinically because it has been shown to promote the development of brain lesions in rats1,2.NMDA receptors are ion channels gated by the major excitatory neurotransmitter in the mammalian central nervous system, glutamate. Glutamate-mediated signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception3.In rats, MK-801 has the ability to induce a characteristic behavioral syndrome with ataxia, stereotypic behavior and hyperlocomotion. In addition, the compound can induce necrosis in a small population of neurons in the cortex of rats4.It has also been discerned that MK-801 induces schizophrenia-like symptoms in rodents, including cognitive functions5.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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