| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C7H9IN2O |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). It reactivates nerve agent-inhibited AChE through direct nucleophilic attack by its oxime moiety on the phosphorus center of the bound nerve agent, and it serves as an antidote for organophosphate poisoning[1][2]. It is supplied as a light yellow to yellow solid (C7H9IN2O, MW 264.06) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 94-63-3 |
|---|---|
| Molecular Formula | C7H9IN2O |
| Molecular Weight | 264.06 g/mol |
| Purity | 98.0% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | C[N+]1=CC=CC=C1/C=N/O.[I-] |
| Target | AChE |
| Signaling Pathway | Neuronal Signaling |
| Solubility | In Vitro: DMSO: 250 mg/mL (946.75 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 250 mg/mL (946.75 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vivo
In mice, Pralidoxime iodide (10-150 mg/kg; a single intramuscular dose) counteracts paraoxon-induced respiratory toxicity[3].
| Animal Model | Male F1B6D2 mice (toxic but non-lethal model of diethylparaoxon in awake, unrestrained mice)[3] |
|---|---|
| Dosage | 10, 50, 100 and 150 mg/kg |
| Administration | Intramuscularly, once |
| Result | Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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