Pridopidine

Pridopidine is a small molecule with neuroprotective potential, primarily investigated for Huntington’s disease, Parkinson’s disease, and schizophrenia. Initially described as a dopamine stabilizer due to its ability to modulate dopaminergic tone without inducing catalepsy, its mechanism is now attributed to high-affinity binding at the sigma-1 receptor. This receptor is implicated in cellular stress responses, neuroprotection, and synaptic plasticity. Pridopidine has demonstrated the ability to restore neuronal function, enhance neurotrophic signaling, and reduce neurodegeneration in preclinical models. Its sigma-1-mediated effects also extend to models of amyotrophic lateral sclerosis (ALS), highlighting its broad therapeutic potential in neurodegenerative disease research.

Classification: Warning

GHS Hazard Statements:

H302, H361d

Precautionary Statement Codes:

P203, P264, P270, P280, P301+P317, P318, P330, P405, and P501

Pridopidine (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-626)

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• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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