| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C13H21ClN2O |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Prilocaine hydrochloride, an amino amide, is a Na/K-ATPase inhibitor. It has neurotoxic effects[1][2]. It is supplied as a white to off-white solid (C13H21ClN2O, MW 256.77).
Physical & Chemical Properties
| CAS Number | 1786-81-8 |
|---|---|
| Molecular Formula | C13H21ClN2O |
| Molecular Weight | 256.77 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CC(NCCC)C(NC1=CC=CC=C1C)=O.Cl |
| Signaling Pathway | Membrane Transporter/Ion Channel |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
In plasma membranes of LM cells (transformed fibroblasts), Prilocaine hydrochloride inhibits Na,K-ATPase more potently at 37 °C (43.8 mM) than at 25 °C (28.2 mM)[2].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Stem Cell Res Ther 2021 Feb 4;12(1):107. PMID: 33541421
