| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C11H12O3S |
| Purity | |
| Activity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Propargyl-Tos is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. It is also a click chemistry reagent that contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules bearing azide groups. It is supplied as a colorless to light yellow liquid (C11H12O3S, MW 224.28) at 98.74% purity.
Physical & Chemical Properties
| CAS Number | 23418-85-1 |
|---|---|
| Molecular Formula | C11H12O3S |
| Molecular Weight | 224.28 g/mol |
| Purity | 98.74% |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| Density | 1.27 g/cm3 |
| SMILES | C#CCCOS(C1=CC=C(C)C=C1)(=O)=O |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related |
| Bioactivity Class | Cleavable Linker |
| Storage | Pure form: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
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