| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Endogenous metabolite |
| Molecular weight | |
| Molecular formula | C20H32O6 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Prostaglandin G2 is a prostaglandin peroxide that acts as a precursor for thromboxane A2 production, inducing platelet aggregation and serotonin release. It also induces cerebral arteriole injury in anesthetized cats through generation of reactive oxygen free radicals, triggering persistent vasodilation, reduced reactivity to hypocapnia, and endothelial damage, and it can be used in studies of cerebral arteriole injury[1][2]. It is supplied as a colorless to light yellow liquid (C20H32O6, MW 368.46) at 99.9% purity.
Physical & Chemical Properties
| CAS Number | 51982-36-6 |
|---|---|
| Molecular Formula | C20H32O6 |
| Molecular Weight | 368.46 g/mol |
| Purity | 99.9% |
| Appearance | Liquid |
| Color | Colorless to light yellow |
| Structure Classification | Ketones, Aldehydes, Acids |
| SMILES | CCCCC[C@H](OO)/C=C/[C@@H]1[C@H]([C@]2([H])C[C@@]1([H])OO2)C/C=C\CCCC(O)=O |
| Signaling Pathway | Immunology/Inflammation; NF-κB; Metabolic Enzyme/Protease |
| Initial Source | Endogenous metabolite |
| Storage | Solution, -20°C, 2 years. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[2]. Kontos H A, et al. Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science, 1980, 209(4462): 1242-1245.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
When Prostaglandin G2 (0.6-1 μg) is incubated with washed human platelets pretreated with Indomethacin, it produces thromboxane A2, an unstable rabbit aorta contracting factor whose half-life is 34 sec at 37 °C and which strongly contracts isolated rabbit aorta strips[1].
In Vivo
In anesthetized cats, Prostaglandin G2 (10 μg/mL; single 15 min exposure; local administration under cranial window) induces cerebral arteriole injury[2].
| Animal Model | Domestic cats (anesthetized with pentobarbital)[2] |
|---|---|
| Dosage | 10 μg/mL |
| Administration | topical application under cranial window; single 15-minute exposure |
| Result | Induced 30% residual arteriolar dilation (percent of control) 1 hour after removal. Reduced arteriolar diameter decrease in response to arterial hypocapnia from 12% to 8% of control. Caused 13.3 endothelial lesions per 2100 μm2 of pial arteriole surface. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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