| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C26H39ClN8O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Protein kinase affinity probe 1 is a novel affinity probe developed for the functional identification of protein kinases (PKs). It is a modified Purvalanol B probe with 50% beads loading, designated Compound S3[1]. It has the molecular formula C26H39ClN8O2 and a molecular weight of 531.09 g/mol.
Physical & Chemical Properties
| CAS Number | 2098621-90-8 |
|---|---|
| Molecular Formula | C26H39ClN8O2 |
| Molecular Weight | 531.09 g/mol |
| SMILES | O=C(NCCCCCCN)C1=CC=C(NC2=C3N=CN(C(C)C)C3=NC(N[C@@H](CO)C(C)C)=N2)C=C1Cl |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
"S" denotes sepharose-bound PKI (Purvalanol B)[1]. Pull-down experiments on HeLa cell lysates are run to determine the effects of PK inhibitor loadings of 0.1, 0.5, 1, 2, 5, 10, 25, and 50%. Higher bead loadings (75 and 100%) are precluded from examination by limited compound solubility and poor reproducibility of the synthesis results. In this study, a loading of 50% is the highest feasible[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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