| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Protein kinase inhibitors 1 (CAS 1365986-44-2) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 1365986-44-2 |
|---|---|
| Molecular Formula | C18H17N5O3S |
| Molecular Weight | 383.42 g/mol |
| SMILES | O=C1C(=CC(C=C2SC(=O)NC2=O)=CN1)C=3C=CC(=NC3)N4CCNCC4 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Protein kinase inhibitors 1 is a novel inhibitor of HIPK2 with an IC50 of 74 nM and Kd of 9.5 nM.
Target(s): Others, DYRK
Signaling pathway(s): Cell Cycle/Checkpoint, Others, Tyrosine Kinase/Adaptors
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
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