| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Microbial — Bacillus and yeast |
| Molecular weight | |
| Molecular formula | C12H20N2O4 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pulcherriminic acid is a cyclic dipeptide that acts as an antimicrobial agent with high affinity for Fe3+, occurring mainly in Bacillus species and yeast. Through a non-enzymatic reaction, it chelates iron ions to form the extracellular red pigment pulcherrimin, which competes for iron and thereby produces an antibacterial effect. It has applications across the food, agriculture, and medical industries[1][2]. It is supplied as a light yellow to yellow solid (C12H20N2O4, MW 256.30) at 98.0% purity.
Physical & Chemical Properties
| CAS Number | 957-86-8 |
|---|---|
| Molecular Formula | C12H20N2O4 |
| Molecular Weight | 256.30 g/mol |
| Purity | 98.0% |
| Appearance | Solid |
| Color | Light yellow to yellow |
| Structure Classification | Cyclopeptides |
| SMILES | OC1=C(CC(C)C)[N+]([O-])=C(O)C(CC(C)C)=[N+]1[O-] |
| Signaling Pathway | Anti-infection |
| Initial Source | Microbial — Bacillus and yeast |
| Solubility | In Vitro: DMSO: 2 mg/mL (7.80 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 2 mg/mL (7.80 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Pulcherriminic acid can block formation of Bacillus subtilis biofilm[2]. In the presence of Fe3+, Pulcherriminic acid can form the insoluble red pigment pulcherrimin, which competes for iron nutrients and thereby inhibits growth of Metschnikowia yeasts[3].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Chem Eng J. 2025 Sep 15.
Developing Bacillus subtilis as cell factory for the production of the natural biocontrol compound pulcherrimin. Bioresour Technol 2025 Jul:427:132433. PMID: 40122349
bioRxiv. 2025 March 18.
