| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Ethyl 4-{(4Z)-4-[(5-nitro-2-furyl)methylene]-3,5-dioxo-1-pyrazolidinyl}benzoate, PYR-41, 4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester |
| Cas No. | |
| Form | Brown Powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in 25 mg/ml DMSO |
| Source | Synthetic |
| Storage |
Pyr-41 inhibits the ubiquitin-activating enzyme E1, thereby modulating the ubiquitination pathway. It is cell permeable and has been used in neuroscience to investigate the role of ubiquitin signaling in neuronal survival, synaptic function, and neurodegenerative disease mechanisms involving protein turnover and stress responses.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
- S24/25- Avoid contact with skin and eyes
Hazard Statements:
- H302 – May be harmful if swallowed
- H317 – May cause an allergic skin reaction
Precautionary Statements:
P280 – Wear protective gloves
Pyr-41 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-330)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Mi L., et al. (2009) J. Biol. Chem. 284: 17039.
