| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Source | Plant — Solanaceae Lycium barbarum L. |
| Molecular weight | |
| Molecular formula | C22H28O5 |
| Purity | |
| SMILES | |
| Form | Liquid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Pyrethrin II is an orally active insecticidal ester of chrysanthemum acid, occurring in Chrysanthemum cinerariifolium and C. coccineum Willd. and serving as an active constituent of pyrethrum extract with low mammalian toxicity. It shows antiparasitic activity and can be used in research on allergic contact dermatitis and parasitic infections[1][2][3][4]. It is supplied as a light yellow to yellow liquid (C22H28O5, MW 372.45) at 31.27% purity.
Physical & Chemical Properties
| CAS Number | 121-29-9 |
|---|---|
| Molecular Formula | C22H28O5 |
| Molecular Weight | 372.45 g/mol |
| Purity | 31.27% |
| Appearance | Liquid |
| Color | Light yellow to yellow |
| Density | 1.12±0.1 g/cm3 |
| Structure Classification | Others |
| SMILES | COC(/C(C)=C/[C@@H]1[C@H](C1(C)C)C(O[C@@H]2C(C)=C(C(C2)=O)C/C=C\C=C)=O)=O |
| Signaling Pathway | Anti-infection |
| Initial Source | Plant — Solanaceae Lycium barbarum L. |
| Solubility | In Vitro: DMSO: 100 mg/mL (268.49 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Pure form: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (268.49 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
In Vivo
Choose the formulation that suits the animal model and route of administration; percentages are volume ratios of the final working solution. Start from a clear DMSO stock (see In Vitro above), add the co-solvents one at a time in the order listed, mixing after each addition, and prepare the working solution fresh on the day of dosing. If precipitation or phase separation occurs, gentle warming or sonication can help.
Protocol 1
| Composition | 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% saline |
|---|---|
| Result | ≥ 2.5 mg/mL (6.71 mM); clear solution |
| How to prepare | Gives a clear solution at ≥ 2.5 mg/mL (saturation not determined). For 1 mL of working solution: add 100 μL DMSO stock (25.0 mg/mL) to 400 μL PEG300; then 50 μL Tween-80; then 450 μL saline to bring the volume to 1 mL. Saline: dissolve 0.9 g sodium chloride in ddH2O and make up to 100 mL. |
Data provided by the manufacturer.
In Vitro
Pyrethrin II is active against P. falciparum (IC50 4.0 μM) and T.b. rhodesiense (IC50 10.6 μM)[1]. In L-6 cells, Pyrethrin II shows low cytotoxicity (IC50 of 95.1 μM)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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Pyrethrin II impairs mitochondrial potential through ROS and MAPK pathways in HT‑22 cells. Neurotoxicology 2026 Jul 13:116:103518. PMID: 42442637
Lett Drug Des Discov. 2025 Nov 25.
