Pyrrolopyrimidine 48

Product details

• Chemical name: 7-benzyl-4-(1-pyridin-2-ylpiperidin-4-yl)oxypyrrolo[2,3-d]pyrimidine.
• Also known as: Pyrrolopyrimidine 14, BDBM14191, N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4-(2-methoxyethyl)piperazin-1-amine
• PubChem CID: 73755149
• Molecular formula: C23H23N5O.
• Purity: >99% (HPLC)
• Concentration: 50 nM - 20 µM.
• Form: Lyophilized powder.
• Solubility: 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: NaV1.7, NaV1.5 channels
• Source: Synthetic
• Activity: Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel with an IC50 value of 0.11 µM. It also blocks NaV1.5 channel with an IC50 of 0.16 µM1.
• Alternative names: Pyrrolopyrimidine 14, BDBM14191, N-{7-cyclohexyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-4-(2-methoxyethyl)piperazin-1-amine

Scientific background

Pyrrolopyrimidine 48 is a blocker of NaV1.7 channel developed using structure-activity relationship of the channel. It blocks human NaV1.7 with an IC50 value of 0.11 µM and NaV1.5 channel with an IC50 of 0.16 µM. It exhibits good selectivity over hERG K+ channel1.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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