| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 5-(chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one.
- CAS number: 1259536-70-3
- Molecular formula: C18H11ClF3N3O.
- Purity: >99%
- Concentration: 1-100 µM.
- Form: Lyophilized Powder
- Solubility: 200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KCNQ channels
- Source: Synthetic
- Activity: QO-40 is a KCNQ channel opener with EC50 of ~7 µM on cloned channels and on native M-current in DRG neurons1.
Scientific background
QO-40 potently enhances KCNQ channels. It has the ability to decrease the firing of overactive neurons. In medicine, this compound is being used for the treatment of epilepsy and neuropathic pain. In a study conducted on Chinese hamster ovary cells, QO-40 managed to shift the half-maximal activation voltage in the hyperpolarizing direction in a concentration-dependent manner1. QO-40 demonstrates EC50 value of approximately 7 µM on cloned channels and on native M-currents expressed in dorsal root ganglia neurons1.The voltage-gated M-type potassium channels of the KV7 family encoded by the KCNQ gene family, plays an important role in controlling neuronal excitability. KCNQ gene family seems to affect migraine and neuropathic pain. Several recent studies have shown that genetic mutations in KCNQ channel can lead to neonatal epilepsy in humans and mice.KCNQ channels are expressed in the sensory system including the trigeminal ganglion neurons and dorsal root ganglion2,3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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