| Field | Specification |
|---|---|
| Alternative names | Mepacrine methanesulfonate; SN-390 methanesulfonate |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C25H38ClN3O7S2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Quinacrine methanesulfonate, also known as Mepacrine methanesulfonate or SN-390 methanesulfonate, is a potent, orally active antimalarial agent with antitumor effects in vitro and in vivo. It inhibits NF-κB and activates p53 signaling, inducing apoptosis in tumor cells[1][2]. It has the molecular formula C25H38ClN3O7S2 and a molecular weight of 592.17 g/mol.
Physical & Chemical Properties
| CAS Number | 316-05-2 |
|---|---|
| Molecular Formula | C25H38ClN3O7S2 |
| Molecular Weight | 592.17 g/mol |
| SMILES | CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.CS(=O)(O)=O.CS(=O)(O)=O |
| Signaling Pathway | Anti-infection; Apoptosis; Autophagy |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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Targeting the G-quadruplex as a novel strategy for developing antibiotics against hypervirulent drug-resistant Staphylococcus aureus. J Biomed Sci 2025 Feb 5;32(1):15. PMID: 39905515
STING activates ZBP1-mediated PANoptosis to defend against HSV-1 retinal infection. J Neuroinflammation 2025 Oct 27;22(1):243. PMID: 41146204
Quinacrine induces autophagy via the Dlg5/AKT pathway to inhibit osteosarcoma cell proliferation and suppresses migration and invasion through the Dlg5/Girdin pathway. Phytomedicine 2025 Sep:145:156981. PMID: 40541124
J Pharm Anal. 2025 Dec 15.
Exposure to high dose of polystyrene nanoplastics causes trophoblast cell apoptosis and induces miscarriage. Part Fibre Toxicol 2024 Mar 7;21(1):13. PMID: 38454452
Inhibition of the NFATc2/FKBP5 axis alleviates microglial neuroinflammation by regulating arachidonic acid metabolism in Parkinson's disease. Brain Behav Immun 2026 Jan 18:134:106296. PMID: 41554345
Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets. Pharmaceutics 2022 Jan 12;14(1):176. PMID: 35057070
bioRxiv. 2025 Nov 11.
University of Saskatchewan. 2020 Jun 22.
