(R)-Avanafil

SKU:BHB21902471
Overview
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(R)-Avanafil (CAS 1638497-26-3) is an inhibitor. Relevant to Metabolic Enzyme/Protease research. Molecular formula C23H26ClN7O3, molecular weight 483.95 g/mol. Also known as (R)-TA1790.
CAS Number 1638497-26-3
Molecular Weight 483.95 g/mol
Storage See Certificate of Analysis
Options selector
Catalog no. Size
HY-18252B-5MG 5 mg
Available Options

Select the variant that best fits your experiment. Availability and lead time may vary by option.

  • Options: Size: 5 mg
  • Lead time: made to order; typically ships within 2–3 weeks.
  • Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
  • Shipping: Room temperature in continental US; may vary elsewhere.
  • Upon receipt: store as stated on the Certificate of Analysis; contact us if you need the condition before ordering.
Field Specification
Alternative names (R)-TA1790
CAS no. 1638497-26-3
Applications
  • Functional Assay (In Vitro)
Molecular weight 483.95
Molecular formula C23H26ClN7O3
SMILES COC1=C(Cl)C=C(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC(N4[C@@H](CO)CCC4)=N2)C=C1
Storage Refer to Certificate of Analysis (CoA) for storage conditions
Shipping Room temperature in continental US; may vary elsewhere.
Catalog no. (Mfr.) HY-18252B
Main SKU BHB21902471
Inhibitors

Compound Overview

(R)-Avanafil, also known as (R)-TA1790, is a selective PDE5 inhibitor with an IC50 of 5.2 nM. It can be used for research of erectile dysfunction[1]. It has a molecular formula of C23H26ClN7O3 and a molecular weight of 483.95 g/mol.

Physical & Chemical Properties

CAS Number 1638497-26-3
Molecular Formula C23H26ClN7O3
Molecular Weight 483.95 g/mol
SMILES COC1=C(Cl)C=C(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC(N4[C@@H](CO)CCC4)=N2)C=C1
Signaling Pathway Metabolic Enzyme/Protease
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Shipping Room temperature in continental US; may vary elsewhere.

Biological Activity

Activity & Target

5.2 nM (PDE5)[1].

Literature Cited

Sources cited in this description. Peer-reviewed publications that used this product are listed under References.

[1]. Sakamoto T, et al. The discovery of avanafil for the treatment of erectile dysfunction: a novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5460-5.

Safety

For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.

Q.How long does this take to ship?
A.This item is produced on request and typically ships within 2–3 weeks.
Q.Can this be used in humans or for diagnostics?
A.No. This product is supplied For Research Use Only. It is not for diagnostic or therapeutic procedures and not for human or veterinary use.

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