| Field | Specification |
|---|---|
| Alternative names | 1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde, Gossypol |
| CAS no. | |
| Applications | |
| Source | Synthetic |
| Molecular weight | |
| Molecular formula | C30H30O8 |
| Purity | |
| Bioactivity | Inducer |
| Activity | |
| Solubility | Soluble to 25 mM in ethanol and in DMSO. |
| SMILES | |
| InChIKey | |
| Form | Dark Yellow Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
R(-)-Gossypol is a natural phenolic compound derived from the cotton plant, known for its pro-apoptotic and enzyme-inhibitory properties. In neuroscience, it has been studied for its ability to modulate apoptotic pathways through regulation of Bcl-2 family proteins and inhibition of calcineurin. These mechanisms are relevant to neurodegenerative diseases characterized by dysregulated cell death and calcium signaling.
Classification: Harmful. May be harmful if inhaled, swallowed or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
- R62- Possible risk of impaired fertility
- R68- Possible risk of irreversible effects
Hazard Phrases:
H351
Precautionary Phrases:
P281
R(-)-Gossypol (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-223)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114.
