| Field | Specification |
|---|---|
| Alternative names | (+)-Cotinine; (R)-Cotinine; (R)-NIH-10498 |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C10H12N2O |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
R-(+)-Cotinine, also known as (+)-Cotinine, (R)-Cotinine, or (R)-NIH-10498, is a Nicotine metabolite that lacks significant activity across a wide range of pharmacological targets. It can enhance the Ach-evoked current in human α7 nAChRs[1]. It has the molecular formula C10H12N2O and a molecular weight of 176.22 g/mol.
Physical & Chemical Properties
| CAS Number | 32162-64-4 |
|---|---|
| Molecular Formula | C10H12N2O |
| Molecular Weight | 176.22 g/mol |
| SMILES | O=C1N(C)[C@@H](C2=CC=CN=C2)CC1 |
| Signaling Pathway | Membrane Transporter/Ion Channel; Neuronal Signaling |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
R-(+)-Cotinine (1 μM) significantly boosts the Ach (40 μM)-evoked current in human α7 nAChRs[1].
In Vivo
On novel object recognition (NOR) performance, R-(+)-Cotinine (0.3-10 mg/kg; a single i.p.) augments the effect of Donepezil at a subthreshold dose (0.5 mg/kg)[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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