| Field | Specification |
|---|---|
| Target | |
| Alternative names | Hif1aHypoxia-inducible factor 1-alpha ELISA Kit; HIF-1-alpha ELISA Kit; HIF1-alpha ELISA Kit |
| UniProt # | |
| Species | |
| Reactivity | |
| Applications | |
| Assay type | |
| Sample type(s) | serum, plasma, tissue homogenates |
| Sensitivity | |
| Detection range | |
| Detection wavelength | |
| Assay time | |
| Catalog no. (Mfr.) | |
| Main SKU |
Background
hypoxia-inducible factor 1α (HIF1A) is a biological molecule commonly studied in epigenetics and nuclear signaling research. It is commonly used as a molecular readout in mechanistic and biomarker-focused studies.
UniProt: O35800
Biological context
Researchers often monitor hypoxia-inducible factor 1α in serum, plasma, and tissue homogenates to better understand themes such as mechanistic biology studies, biomarker-focused profiling, and disease-model research. In many model systems, measured levels can shift with physiology, experimental perturbation, or disease-associated changes, making careful biological interpretation important.
Interpreting changes in measured levels
Depending on sample matrix and study design, increases or decreases in hypoxia-inducible factor 1α may reflect differences in expression, secretion, turnover, or compartmentalization rather than a single mechanism. Interpretation is typically strengthened by evaluating related molecules (for example, complementary pathway markers and controls appropriate to the biological model) and by keeping pre-analytical variables consistent across groups.
Nomenclature
In publications and databases, hypoxia-inducible factor 1α may also appear under names such as Hif1aHypoxia-inducible factor 1-alpha and HIF-1-alpha. When comparing studies, confirm that the reported analyte refers to the same molecule and species context.
Why ELISA data are widely used
ELISA is a common approach for quantitative measurement of proteins and biomarkers in complex samples, enabling comparisons across experimental groups and time points. When integrating results with other readouts, consider species biology, sample type, and the broader pathway context that hypoxia-inducible factor 1α participates in.
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SEX DIFFERENCES IN SYSTEMIC INFLAMMATORY RESPONSE IN LOW HYPOXIA-RESISTANT RATS
I Tsvetkov, A Kosyreva, D Dzhalilova, O Makarova,Morphology,2024
Boosting effects of Cranberry and Cinnamaldehyde for pioglitazone amelioration of liver steatosis in rat via suppression of HIF-1α/Smad/β-catenin signaling
MA Ali,Journal of Functional Foods,2023
Oxygen-Glucose Deprivation in Organotypic Hippocampal Cultures Leads to Cytoskeleton Rearrangement and Immune Activation: Link to the Potential Pathomechanism of Ischaemic Stroke
N Bryniarska-Kubiak,Cells,2023
Cubic multi-ions-doped Na2TiO3 nanorod-like coatings: Structure-stable, highly efficient platform for ions-exchanged release to immunomodulatory promotion on vascularized bone apposition
Dongmei Yu,Bioactive Materials,2022
Assessment of the effects of ischaemia/hypoxia on angiogenesis in rat myofascial trigger points using colour Doppler flow imaging
F Jiang,PeerJ,2020
Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
Marschner RA, et al,Plos One,2019
A Promising Approach to Integrally Evaluate the Disease Outcome of Cerebral Ischemic Rats Based on Multiple-Biomarker Crosstalk
Guimei Ran.et al,DiseaseMarkers,2017
Expression and specific activities of carbamoyl phosphate synthetase 1 in chronic hypoxic rats
Nikmah U A.et al,Medical Journal of Indonesia,2016
Measurement of levels of lung HIF-1伪 protein in response to tapering for 14- and 21-day with nigella sativa supplementation in maturing rat, with histological study
Ehsan Arabzadeh.et al,Sport Sciences for Health,2015
Influence of thyroid state on cardiac and renal capillary density and glomerular morphology in rats
Rodriacuteguez-Goacutemez I et al,J Endocrinol,2013
