| Field | Specification |
|---|---|
| Target | |
| Alternative names | KlKlotho ELISA Kit; EC 3.2.1.31) [Cleaved into: Klotho peptide] ELISA Kit |
| UniProt # | |
| Species | |
| Reactivity | |
| Applications | |
| Assay type | |
| Sample type(s) | serum, plasma, tissue homogenates |
| Sensitivity | |
| Detection range | |
| Detection wavelength | |
| Assay time | |
| Catalog no. (Mfr.) | |
| Main SKU |
Background
Klotho (KL) is a biological molecule commonly studied in developmental biology research. It is commonly used as a molecular readout in mechanistic and biomarker-focused studies.
UniProt: Q9Z2Y9
Biological context
Researchers often monitor Klotho in serum, plasma, and tissue homogenates to better understand themes such as cell differentiation programs, tissue morphogenesis, and stem cell regulation. In many model systems, measured levels can shift with physiology, experimental perturbation, or disease-associated changes, making careful biological interpretation important.
Interpreting changes in measured levels
Depending on sample matrix and study design, increases or decreases in Klotho may reflect differences in expression, secretion, turnover, or compartmentalization rather than a single mechanism. Interpretation is typically strengthened by evaluating related molecules (for example, morphogen-related factors, differentiation markers, and signaling ligands) and by keeping pre-analytical variables consistent across groups.
Nomenclature
In publications and databases, Klotho may also appear under names such as KlKlotho and EC 3.2.1.31) [Cleaved into: Klotho peptide]. When comparing studies, confirm that the reported analyte refers to the same molecule and species context.
Why ELISA data are widely used
ELISA is a common approach for quantitative measurement of proteins and biomarkers in complex samples, enabling comparisons across experimental groups and time points. When integrating results with other readouts, consider species biology, sample type, and the broader pathway context that Klotho participates in.
Can’t Find What You’re Looking For? We can help you source the best match or customize an ELISA solution for your study. Options may include alternative target synonyms, different species reactivity, sample type/matrix compatibility (serum/plasma/lysate/supernatant), assay format (sandwich/competitive), sensitivity/range, detection chemistry (colorimetric/fluorescent/chemiluminescent), plate format (pre-coated/uncoated, strips vs full plate), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
Klotho protein alleviates heart ischemia/reperfusion injury and oxidative stress through regulation of the NOS/MMP pathway
A Olejnik, A Krzywonos-Zawadzka, I Sambor,Scientific Reports,2025
Genetically conditioned interaction among micro RNA‐155, alpha‐klotho, and intra‐renal RAS in male rats: Link to CKD progression
LM Harrison‐Bernard, L Raij, RX Tian,Physiological Reports,2024
Brij® integrated bilosomes for improving the transdermal delivery of niflumic acid for effective treatment of osteoarthritis: In vitro characterization, ex vivo permeability assessment, and in vivo study
MA Abdelbari,International journal of pharmaceutics,2023
Klotho protein contributes to cardioprotection during ischaemia/reperfusion injury
A Olejnik,J Cell Mol Med,2020
Biological effects of dosing aerobic exercise and neuromuscular electrical stimulation in rats
Dalise .et al,Sci Rep,2017
Klotho and S100A8/A9 as DiscriminativeMarkers between Pre-Renal and Intrinsic Acute Kidney Injury.
Kim AJ.et al,PLoS One.,2016
