| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 14 kDa laminin-binding protein (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) (Gal-1) |
| Conjugate | |
| Endotoxin Level | |
| Expression System | |
| Form | Liquid or Lyophilized powder |
| Function | |
| Molecular Weight | |
| Product Type | |
| Protein Length | |
| Purity | |
| Reconstitution | |
| Species | |
| Storage | |
| Target | |
| UniProt # |
Overview
This Recombinant Protein provides recombinant LGALS1 from Homo sapiens (Human), produced in E.coli (region 2-135aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).
Key elements and design rationale
- Region: 2-135aa (domain boundaries can affect binding/activity readouts).
- Expression host: E.coli (may differ from native PTMs/processing).
- Tag(s): His, Myc (supports purification/detection; consider tag effects in controls).
Biological background
Also reported as 14 kDa laminin-binding protein (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) (Gal-1). Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Research relevance and current trends
- Activity assay development for kinetics, substrate scope, and inhibitor/activator profiling.
- Use of recombinant standards to improve assay calibration and cross-study comparability.
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Common research applications
- Standard curve or spike-in reference for quantitative assays involving LGALS1
- Enzymatic activity measurements with defined substrates/cofactors (assay-dependent)
- Compound screening using concentration–response concepts (assay-dependent)
Notes for experimental interpretation
- Recombinant constructs may not capture all native isoforms or PTMs.
- Consider tag- or host-related effects when interpreting binding or activity.
- Use appropriate blanks and matrix/control concepts to separate signal from background.
Can’t Find What You’re Looking For? We can help you source the best match or customize a recombinant protein solution for your study. Options may include species (human/mouse/rat), protein region/domain (full-length vs fragment), tag or label (His/GST/FLAG/biotin/fluorescent), expression system (E. coli/HEK293/insect), purity grade, formulation (buffer, carrier-free, glycerol-free), activity/functional validation (binding or enzymatic assays), endotoxin level (low-endotoxin for cell-based work), mutants/variants (point mutations, isoforms), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
