| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | CD-MPR, MPR46, MPR 46, 46-KDa Mannose 6-Phosphate Receptor, MPR-46. |
| Cellular Localization | |
| Expression System | |
| Form | Filtered White lyophilized (freeze-dried) powder. |
| Formulation | |
| Product Type | |
| Protein Length | |
| Protein Size | |
| Purity | |
| Solubility | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it on cell culture. |
| Source | Escherichia Coli. |
| Species | |
| Storage | |
| Target |
Recombinant Human Mannose-6-Phosphate Receptor (242-277) is supplied as a recombinant protein for in vitro research use.
Background
Mannose 6-phosphate receptors are membrane proteins which take part in the intracellular transport of lysosomal enzymes. These receptors recognize and sort lysosomal hydrolases, facilitate their delivery to lysosomes via endocytic pathways. M6PR binds to mannose 6-phosphate (M6P) residues on newly synthesized lysosomal enzymes in the Golgi apparatus, directing them to lysosomes. After delivering enzymes to lysosomes, M6PRs are recycled back to the cell surface. This mechanism is critical for maintaining cellular homeostasis and efficient enzyme delivery. M6PRs may also play a role in signaling pathways, influencing cellular responses to stress and metabolic changes. Mutations or dysfunction in M6PRs can cause lysosomal storage disorders, emphasizing their importance in human health. Recombinant M6PR has significant implications in therapeutic development, mainly in understanding lysosomal storage diseases and enhancing enzyme replacement therapies.
Product format
Provided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.
What is the purity of Recombinant Human Mannose-6-Phosphate Receptor (242-277) (Human)?
What buffer / formulation is this protein supplied in?
How should Recombinant Human Mannose-6-Phosphate Receptor (242-277) (Human) be stored?
What expression system was used to produce this protein?
Is this protein approved for clinical or in vitro diagnostic use?
Can I request a custom size, tag variant, or formulation?
Can’t Find What You’re Looking For? We can help you source the best match or customize a recombinant protein solution for your study. Options may include species (human/mouse/rat), protein region/domain (full-length vs fragment), tag or label (His/GST/FLAG/biotin/fluorescent), expression system (E. coli/HEK293/insect), purity grade, formulation (buffer, carrier-free, glycerol-free), activity/functional validation (binding or enzymatic assays), endotoxin level (low-endotoxin for cell-based work), mutants/variants (point mutations, isoforms), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
