| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | BR3-Fc, SS-79 |
| Cas No. | |
| Expression System | |
| Form | Liquid |
| Product Type | |
| Purity | |
| Species | |
| Storage | |
| Target | |
| UniProt # |
Scientific Background
Tumor necrosis factor ligand superfamily member 13B (CD257/BAFF) is a ~31 kDa protein. Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Product Description
Briobacept (HV212036) is a research-grade recombinant antibody targeting CD257. Produced in mammalian cells with native-like glycosylation. Highlights- Research Grade — For PK/PD studies, assay development, and ADA research.
- Native Glycosylation — Mammalian expression ensures native-like patterns.
Expression System: Mammalian Cells
Protein Specifications
| Species Reactivity | Human |
|---|---|
| Structure | Fusion - [TNFRSF13C (tumor necrosis factor receptor (TNFR) superfamily member 13C, BAFFR, BR3, B cell activating factor receptor, CD268)]2 - IGHG1 Fc (Fragment constant) |
| Target | BAFF, ZTNF4, BLYS, Tumor necrosis factor ligand superfamily member 13B, Dendritic cell-derived TNF-like molecule, TALL-1, TNF- and APOL-related leukocyte expressed ligand 1, BLyS, B lymphocyte stimulator, TNFSF13B, CD257, TNFSF20, TALL1, B-cell-activating factor |
| Purification | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Form | Liquid |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Expression System | Mammalian Cells |
| UniProt | Q9Y275 |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
Applications
| Application |
|---|
| ELISA |
| Functional Assay |
| In Vivo Studies |
Safety & Handling
Customization & Add-ons: Can't find the protein you need—or require a custom format for your assay? We can help you source the best match or support custom recombinant protein solutions for diverse research needs, including expression system selection, tag and fusion options (His, Fc, biotin), purification grade options, formulation preferences (buffer selection, carrier-free, lyophilized or liquid), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
