| Field | Specification |
|---|---|
| Mfr No | |
| Cas No. | |
| Expression System | |
| Form | Liquid |
| Product Type | |
| Purity | |
| Species | |
| Storage | |
| Target | |
| UniProt # |
Scientific Background
Activin receptor type-2B (ACVR2B) is a ~57 kDa protein. Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Wit
Product Description
Cibotercept (HC570016) is a research-grade recombinant antibody targeting ACTR-IIB. Produced in mammalian cells with native-like glycosylation. Highlights- Research Grade — For PK/PD studies, assay development, and ADA research.
- Native Glycosylation — Mammalian expression ensures native-like patterns.
Expression System: Mammalian Cells
Protein Specifications
| Species Reactivity | Human |
|---|---|
| Structure | Human ACTR-IIB extracellular domain (ECD) fragment fused via the peptide linker to a human IgG1 Fc fragment |
| Target | ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B |
| Purification | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Form | Liquid |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Expression System | Mammalian Cells |
| UniProt | Q13705 |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
Applications
| Application |
|---|
| ELISA |
| Functional Assay |
| In Vivo Studies |
Safety & Handling
Customization & Add-ons: Can't find the protein you need—or require a custom format for your assay? We can help you source the best match or support custom recombinant protein solutions for diverse research needs, including expression system selection, tag and fusion options (His, Fc, biotin), purification grade options, formulation preferences (buffer selection, carrier-free, lyophilized or liquid), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
