| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | ABBV-621, PR-1625011 |
| Cas No. | |
| Expression System | |
| Form | Liquid |
| Product Type | |
| Purity | |
| Species | |
| Storage | |
| Target | |
| UniProt # |
Scientific Background
Tumor necrosis factor receptor superfamily member 10B (CD262/TRAIL-R2) is a ~47 kDa protein. Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Product Description
Eftozanermin Alfa (HT348136) is a research-grade recombinant antibody targeting CD262. Produced in mammalian cells with native-like glycosylation. Highlights- Research Grade — For PK/PD studies, assay development, and ADA research.
- Native Glycosylation — Mammalian expression ensures native-like patterns.
Expression System: Mammalian Cells
Protein Specifications
| Species Reactivity | Human |
|---|---|
| Structure | Fusion - [Homo sapiens TNFSF10 (TNF superfamily member 10, tumor necrosis factor (ligand) superfamily, member 10)]2 - Homo sapiens IGHG1 Fc (Fragment constant) |
| Target | TRAILR2, TRAIL-R2, Death receptor 5, CD262, DR5, Tumor necrosis factor receptor superfamily member 10B, ZTNFR9, TRAIL receptor 2, TRICK2, TNFRSF10B, KILLER, TNF-related apoptosis-inducing ligand receptor 2 |
| Purification | Protein A/G purified from cell culture supernatant. |
| Purity | >95% purity as determined by SDS-PAGE. |
| Form | Liquid |
| Storage Buffer | 0.01M PBS, pH 7.4. |
| Expression System | Mammalian Cells |
| UniProt | O14763 |
| Stability & Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
Applications
| Application |
|---|
| ELISA |
| Functional Assay |
| In Vivo Studies |
Safety & Handling
Customization & Add-ons: Can't find the protein you need—or require a custom format for your assay? We can help you source the best match or support custom recombinant protein solutions for diverse research needs, including expression system selection, tag and fusion options (His, Fc, biotin), purification grade options, formulation preferences (buffer selection, carrier-free, lyophilized or liquid), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
1. Hymowitz, SG. et al. (1999) Molecular cell 4, 563-71. PMID: 10549288
