| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized Powder |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Natural |
| Storage | |
| Target |
Product details
- Chemical name: 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)- 3a,3b,6,6a,9a,10,11,11aoctahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9 b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneaceta.
- Also known as: Reciniferatoxin, RTX
- CAS number: 57444-62-9
- Molecular formula: C37H40O9.
- Purity: 95-98% (HPLC)
- Concentration: 20 nM - 1 µM.
- Form: Lyophilized Powder
- Solubility: Methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: TRPV1 channels
- Source: Natural
- Activity: Resiniferatoxin is a potent and selective activator of the TRPV1 (Vanilloid/Capsaicin receptor 1) channel1.
- Alternative names: Reciniferatoxin, RTX
Scientific background
Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons.2Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensitization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.1
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Cited application(s)
Electrophysiology
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