| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C22H12N4O4S2 |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
RGB-1 selectively binds and stabilizes RNA G-quadruplex structures, thereby reducing expression of the NRAS proto-oncogene in breast cancer cells. It can serve as a tool for investigating the cellular functions of RNA G-quadruplex structures and identifying novel mRNA G-quadruplex-forming sequences, and it is applicable to breast cancer research[1]. It is a light yellow to yellow solid (C22H12N4O4S2, MW 460.49).
Physical & Chemical Properties
| CAS Number | 930455-91-7 |
|---|---|
| Molecular Formula | C22H12N4O4S2 |
| Molecular Weight | 460.49 g/mol |
| Appearance | Solid |
| Color | Light yellow to yellow |
| SMILES | O=C1C2=C(SC=C2C3=CC=CO3)N=C4N1CC5=NC6=C(C(N5C4)=O)C(C7=CC=CO7)=CS6 |
| Signaling Pathway | GPCR/G Protein; MAPK/ERK Pathway |
| Solubility | In Vitro: DMSO: 0.5 mg/mL (1.09 mM; Requires sonication and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 0.5 mg/mL (1.09 mM) | requires sonication and warming and heat to 60°C; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
RGB-1 binds specifically to the TERRA RNA G-quadruplex with an apparent Kd of 5.9 μM and shows minimal to no binding to DNA G-quadruplex structures[1]. In a cell-free system, RGB-1 selectively reduces translation of mRNA that carries a TERRA RNA G-quadruplex in its 5' UTR[1]. RGB-1 (5-20 μM) reduces NRAS protein expression in MCF-7 cells in a dose-dependent manner, without changing NRAS mRNA levels[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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