| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C23H23N5 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
RIP1 kinase inhibitor 4 is a BBB-penetrable inhibitor of RIP1 kinase, with an EC50 of less than 100 nM, and it can be used for research on diseases related to programmed cell necrosis[1]. It is also a click chemistry reagent containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules bearing azide groups. It has a molecular formula of C23H23N5 and a molecular weight of 369.46 g/mol.
Physical & Chemical Properties
| CAS Number | 2919836-00-1 |
|---|---|
| Molecular Formula | C23H23N5 |
| Molecular Weight | 369.46 g/mol |
| SMILES | NC(N=C1)=NC=C1C#CC2CCC(C2)N3N=C4C(CCC4C5=CC=CC=C5)=C3 |
| Target | RIPK1 |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target[1]
|
RIPK1 ≤ 1000 nM nM (EC50) |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Su, Yaning, et al. Preparation of pyrazole and triazole heterocycle derivative as RIP1 kinase inhibitor. Patent. WO2023040870.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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