| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C13H17F2NO2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
RIP1 kinase inhibitor 5 is a potent inhibitor of RIP1, which functions as a checkpoint kinase controlling tumor immunity[1]. It is similar to SIR1-365, which inhibits necrosis and iron-dependent cell death activity[2]. It is supplied as a white to off-white solid (C13H17F2NO2, MW 257.28) at 98.49% purity.
Physical & Chemical Properties
| CAS Number | 2428422-17-5 |
|---|---|
| Molecular Formula | C13H17F2NO2 |
| Molecular Weight | 257.28 g/mol |
| Purity | 98.49% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | CCC(C)(C)C(N(CC1=CC(F)=CC(F)=C1)O)=O |
| Signaling Pathway | Apoptosis |
| Solubility | In Vitro: DMSO: ≥ 100 mg/mL (388.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) * "≥" means soluble, but saturation unknown. |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Su Yaning, et al. Preparation of cyrstalline forms of RIP1 inhibitor. World Intellectual Property Organization, WO2023066368 A1. 2023-04-27.
[2]. Su Yaning, et al. Preparation of substituted amides as RIP1 inhibitors. World Intellectual Property Organization, WO2020103859 A1. 2020-05-28.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | ≥ 100 mg/mL (388.68 mM) | use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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