| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H19F2N5O2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
RIP1 kinase inhibitor 8 is a potent, highly selective dihydropyrazole (DHP) inhibitor of RIP1 kinase with an IC50 of 20 nM. It prevents necrotic cell death and shows a favorable pharmacokinetic profile across multiple species[1]. It has the molecular formula C18H19F2N5O2 and a molecular weight of 375.37 g/mol.
Physical & Chemical Properties
| CAS Number | 2226735-54-0 |
|---|---|
| Molecular Formula | C18H19F2N5O2 |
| Molecular Weight | 375.37 g/mol |
| SMILES | O=C(C1CCN(C2=NN=C(O2)C)CC1)N3[C@H](C4=CC(F)=CC(F)=C4)CC=N3 |
| Signaling Pathway | Apoptosis |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 20 nM (RIP1)[1]
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
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