| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C41H58N10O12S |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
RNA polymerase II-IN-2 inhibits RNA polymerase II, with a Ki of 74.1 nM, and it inhibits Pol II-mediated transcription while inducing cytotoxicity in mammalian cells. It serves as a payload for antibody-drug conjugates (ADCs) and has been applied in cancer research[1]. It has the molecular formula C41H58N10O12S (MW 915.02).
Physical & Chemical Properties
| CAS Number | 2891451-33-3 |
|---|---|
| Molecular Formula | C41H58N10O12S |
| Molecular Weight | 915.02 g/mol |
| SMILES | O=C([C@H](C(CC)CC)NC(CNC1=O)=O)NCC(N[C@@H]2C(N[C@H](C(N3C[C@@H](C[C@H]3C(N[C@H](C(N[C@H]1CC4=C(S[C@H]2C)NC5=C4C=CC=C5)=O)[C@H]([C@H](CO)O)C)=O)O)=O)CC(N)=O)=O)=O |
| Target | RNA Polymerase |
| Signaling Pathway | Antibody-Drug Conjugate/ADC Related; Cell Cycle/DNA Damage |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
RNA polymerase II-IN-2 (20iii) is nearly twice as cytotoxic as α-amanitin to CHO cells (normalized IC50 value of 0.61)[1]. RNA polymerase II-IN-2 is 5-fold more cytotoxic than α-amanitin in HEK293 cells (normalized IC50 value of 0.20)[1]. RNA polymerase II-IN-2 shows greater cytotoxicity than α-amanitin toward HeLa cells, with a normalized IC50 value of 0.60[1]. Toward HepG2 liver-derived cells, RNA polymerase II-IN-2 is significantly less cytotoxic than α-amanitin, with a normalized IC50 value of 2.7[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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