| Field | Specification |
|---|---|
| Mfr No | |
| Product Type | |
| Storage |
RNase A is a pancreatic bovine endoribonuclease that cleaves single-stranded RNA by hydrolysis at cytosine and uracil residues. This enzyme is highly effective for the removal of RNA from plasmid DNA preparations, making it an essential tool in nucleic acid purification protocols. RNase A helps ensure clean DNA samples by efficiently degrading contaminating RNA.
| Specification | Value |
|---|---|
| Enzyme Type | RNase |
| Format | Enzyme Only |
| Storage Conditions | Store all components at -20°C . |
RNase A cleaves single-stranded RNA 3′ to pyrimidine residues (C and U), leaving 2′,3′-cyclic phosphate and 5′-hydroxyl termini. It is active across a broad pH range (4–10) and does not require divalent cations. It has no detectable activity on double-stranded RNA or DNA.
Yeasen Biotechnology supports custom enzyme solutions across multiple service lines — from GMP-grade bulk supply to directed enzyme engineering. Contact BioHippo to discuss requirements and initiate a project inquiry.
▶ GMP-Grade & Bulk Supply
Select Yeasen enzymes are available in GMP grade, manufactured in an ISO 13485-certified UCF.ME™ ultra-clean molecular enzyme facility with FDA Drug Master File (DMF) support.
- GMP-grade release testing and CoA documentation
- ISO 13485-certified production facility
- Scalable from milligram to multi-gram quantities
- Consistent lot-to-lot activity specifications
▶ Glycerol-Free & Custom Formulation
Glycerol-free enzyme formats are available for applications requiring lyophilization compatibility, liquid handling automation, or direct IVD master mix integration.
- Glycerol-free liquid format (standard and custom buffers)
- Lyophilization-ready enzyme preparation
- Custom reaction buffer optimization for specific assay conditions
- Compatible with freeze-drying workflows for point-of-care formats
▶ Molecular IVD RDC Service
Yeasen's Research and Development Contracting (RDC) team delivers end-to-end solutions for molecular diagnostic product development, covering enzyme selection through clinical validation support.
- Enzyme selection and performance matching
- Primer/probe design and reaction buffer optimization
- Sensitivity, specificity, and precision validation studies
- Stability studies and SNP evaluation
- Instrument platform compatibility assessment
▶ ZymeEditor™ Enzyme Engineering
Yeasen's proprietary ZymeEditor™ directed evolution and rational design platform enables the development of custom enzyme variants with tailored performance characteristics not available in off-the-shelf products.
- Directed evolution for enhanced thermostability, processivity, or fidelity
- Rational design for altered substrate specificity or cofactor requirements
- Library screening from Yeasen's proprietary enzyme variant collection
- Scale-up to commercial quantities upon candidate confirmation
ⓘ Customization services are fulfilled by Yeasen Biotechnology. Lead times and minimum order quantities vary by service type. Contact BioHippo for project scoping and pricing.
