| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | B8279, 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one, Ro 20 1724, RO 20-1724, 4-(3-butoxy-4-methoxy-benzyl)imidazolidin-2-one |
| Cas No. | |
| Form | White powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (200 mg/ml) or ethanol (40 mg/ml) |
| Source | Synthetic |
| Storage |
Ro 20-1724 is a selective inhibitor of cyclic AMP-specific phosphodiesterase type IV (PDE4). In neuroscience, it is used to elevate intracellular cAMP levels, thereby enhancing memory formation, synaptic plasticity, and neuroprotection. PDE4 inhibitors like Ro 20-1724 have been explored for their therapeutic potential in neurodegenerative diseases, including Alzheimer's and Huntington's disease, due to their ability to modulate inflammatory responses and support neuronal survival. Its role in cAMP signaling makes it a valuable compound for studying second messenger systems in the brain.
Classification: Not a hazardous substance or mixture.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Ro 20-1724 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-527)
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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