| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | Up to 100 mM in DMSO or Ethanol. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 2-[[4-amino-5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidin-2-yl]amino]propane-1,3-diol.
- CAS number: 1050670-85-3
- Molecular formula: C17H23IN4O4.
- Purity: >98% (HPLC)
- Concentration: 0.2 nM - 0.2 µM.
- Form: Lyophilized powder.
- Solubility: Up to 100 mM in DMSO or Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: P2X3 receptors
- Source: Synthetic
- Activity: Ro-51 is a highly potent and selective antagonist of P2X3 and P2X2/3 receptors. It has been shown to inhibit rat homomeric P2X3 and human heteromeric P2X2/3 receptors with pIC50 values of 8.7 and 8.3, respectively, whilst exhibiting no antagonistic activity at other P2X receptor family members at up to 10 µM1.
Scientific background
Ro-51 is a highly potent and selective antagonist of P2X3 and P2X2/3 receptors. It inhibits rat homomeric P2X3 and human heteromeric P2X2/3 and demonstrates IC50 values of 2 and 5 nM respectively1.Ro-51 has been shown to reduced hyperalgesia and mechanical allodynia in inflammatory and neuropathic pain models1,2. The compound is highly selective for P2X3 and P2X2/3, showing no antagonistic activity at other P2X receptor family members1.P2X receptors are a family of ion channels gated by ATP. They are widely localized in cell types of almost every origin, including neuronal, muscular, epithelial and immune and have been shown to play a pivotal role in models of various pain conditions3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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