| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C16H11ClFN3OS |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of ROCK, ERK, GSK and AGC protein kinases, with potential application in research on proliferative, cardiac and neurodegenerative diseases[1]. It is supplied as a white to off-white solid (C16H11ClFN3OS, MW 347.79) at 99.52% purity.
Physical & Chemical Properties
| CAS Number | 692870-25-0 |
|---|---|
| Molecular Formula | C16H11ClFN3OS |
| Molecular Weight | 347.79 g/mol |
| Purity | 99.52% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C(NC1=NC(C2=CC=NC=C2)=CS1)CC3=C(F)C=CC=C3Cl |
| Signaling Pathway | Cell Cycle/DNA Damage; TGF-beta/Smad; Stem Cell/Wnt; Cytoskeleton; MAPK/ERK Pathway; PI3K/Akt/mTOR |
| Solubility | In Vitro: DMSO: 12.5 mg/mL (35.94 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description. Peer-reviewed publications that used this product are listed under References.
[1]. Jingrong Cao, et al. Compositions useful as inhibitors of rock and other protein kinases. WO2004041813A1.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 12.5 mg/mL (35.94 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
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