| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone |
| Cas No. | |
| Form | Orange to brown solid. |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 2 mM in ethanol and to 20 mM in DMSO. |
| Source | Synthetic |
| Storage |
Rottlerin is a natural polyphenol known for its inhibitory effects on protein kinase C (PKC) and Ca²⁺/calmodulin-dependent kinase III. In neuroscience, Rottlerin is recognized for its neuroprotective properties, particularly in models of Parkinson’s disease. It acts as a mitochondrial uncoupler, depolarizing membrane potential and influencing energy metabolism. Rottlerin also induces autophagy by inhibiting mTORC1 signaling, a pathway critical for neuronal survival and protein clearance. Its ability to modulate potassium channels and reduce oxidative stress further supports its application in neurodegenerative disease research. Rottlerin is frequently used to explore the interplay between mitochondrial function, autophagy, and neuronal health.
Classification: Not WHMIS controlled.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Rottlerin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-394)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Wu S., et al. (2007) J Cell Physiol. 210(3): 655-66.
3. Soltoff S. (2001) J Biol Chem. 276(41): 37986-92.
4. Balgi A., et al. (2009) PLoS One. 4(9): e7124.
