(RS)-(Tetrazol-5-yl)glycine

Product details

• Chemical name: 2-amino-2-(2H-tetrazol-5-yl)acetic acid.
• Also known as: Tet-glycine, Tetrazolylglycine, Tetrazol-5-yl-gly, 5-Tetrazolyl-glycine, LY 285 265
• CAS number: 138199-51-6
• Molecular formula: C3H5N5O2.
• Purity: >98%
• Concentration: 0.1-25 µM.
• Form: Lyophilized powder.
• Solubility: Soluble up to 25 mM in water, with gentle heating. Centrifuge all product preparations before use (10000 x g 5 min).
• Reconstitution: Soluble up to 25 mM in water, with gentle heating. Centrifuge all product preparations before use (10000 x g 5 min).
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: NMDA receptors
• Source: Synthetic
• Activity: (RS)-(Tetrazol-5-yl)glycine is a highly potent and selective NMDA receptor agonist (significantly more potent than NMDA or glutamate), inhibiting [3H]glutamate binding to rat brain NMDA receptors with IC50 of 36 nM1. in vitro, it activates NR1/NR2A NMDA receptors with EC50 of 1.77 µM2.
• Alternative names: Tet-glycine, Tetrazolylglycine, Tetrazol-5-yl-gly, 5-Tetrazolyl-glycine, LY 285 265

Scientific background

(RS)-(Tetrazol-5-yl)glycine is a synthetic compound that acts as highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist. The compound is significantly more potent than NMDA or glutamate. When given to neonatal rats, (RS)-(Tetrazol-5-yl) glycine was found to be highly potent convulsant1.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. They also mediate physiological functions such as learning and memory formation and participate in glutamate excitotoxicity2.(RS)-(Tetrazol-5-yl)glycine inhibits [3H]glutamate binding to rat brain NMDA receptors with an IC50 value of 36 nM1. in vitro studies show that (RS)-(Tetrazol-5-yl)glycine can activate NR1/NR2A NMDA receptors with an EC50 value of 1.77 µM3.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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