| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C20H26ClF3N4O3 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
RS100329 hydrochloride is a potent, selective α1A-adrenoceptor antagonist, with pKi values of 9.6, 7.9, and 7.5 for α1A, α1D, and α1B, respectively. It inhibits reflex urethral contractions and can be used to study benign prostatic hyperplasia[1][2]. It is supplied as a white to off-white solid (C20H26ClF3N4O3, MW 462.89) at 99.68% purity.
Physical & Chemical Properties
| CAS Number | 1215654-26-4 |
|---|---|
| Molecular Formula | C20H26ClF3N4O3 |
| Molecular Weight | 462.89 g/mol |
| Purity | 99.68% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=C1N(CCCN2CCN(C3=CC=CC=C3OCC(F)(F)F)CC2)C(C(C)=CN1)=O.[H]Cl |
| Signaling Pathway | GPCR/G Protein; Neuronal Signaling |
| Solubility | In Vitro: DMSO: 31.25 mg/mL (67.51 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
Activity & Target
pKi: 9.6 (α1A-adrenoceptor), 7.9 (α1D-adrenoceptor) and 7.5 (α1B-adrenoceptor)[2]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 31.25 mg/mL (67.51 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); protect from light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
Contractions to Norepinephrine in human lower urinary tract (LUT) tissues are antagonized by RS100329 hydrochloride in a surmountable and concentration-dependent manner[2].
In Vivo
In Sprague Dawley rats, RS100329 hydrochloride (0.01-0.1 mg/kg; i.v.) lowers baseline urethral pressure and inhibits reflex urethral contractions[1].
| Animal Model | Sprague Dawley rats (300-390 g)[1] |
|---|---|
| Dosage | 0.01-0.1 mg/kg |
| Administration | Intravenous injection |
| Result | Caused a fall in baseline urethral pressure reaching a maximum of 23%. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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