| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (3R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| Cas No. | |
| Form | Off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (25 mg/ml) or EtOH (~15 mg/ml) |
| Source | Synthetic |
| Storage |
Ruxolitinib is a selective inhibitor of Janus-associated kinases (JAK1 and JAK2), key mediators in cytokine signaling pathways. While primarily developed for hematologic malignancies and inflammatory disorders, Ruxolitinib has gained attention in neurodegenerative disease research due to its ability to modulate neuroinflammation. Dysregulated JAK/STAT signaling is implicated in several neurodegenerative conditions, including Alzheimer's and Parkinson's disease. By suppressing pro-inflammatory cytokine signaling, Ruxolitinib may reduce microglial activation and neuronal damage. Its potential to cross the blood-brain barrier further supports its exploration as a neuroprotective agent.
Classification: Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 1 Danger
Target Organ Systemic Toxicity (repeated exposure), Category 2
Toxic To Reproduction, Category 2 Warning
Acute Toxicity:
Oral, Category 4
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
H315:
Causes skin irritation.
H318:
Causes serious eye damage
H373:
May cause damage to organs through prolonged or repeated exposure.
H361:
Suspected of damaging fertility or the unborn child.
H302:
Harmful if swallowed.
P264:
Wash hands thoroughly after handling.
P280:
Wear protective gloves/clothing and eye/face protection as specified by the
manufacturer/supplier or the competent authority.
P260:
Do not breathe dust/fume/gas/mist/vapours/spray.
P201:
Obtain special instructions before use.
P202:
Do not handle until all safety precautions have been read and understood.
P281:
- Use personal protective equipment as required.
- P302+352: IF ON SKIN: Wash with plenty of soap and water.
- P332+313: If skin irritation occurs, get medical advice/attention.
P362:
Take off contaminated clothing and wash before re-use.
P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact
lenses, if present and easy to do. Continue rinsing.
P310:
Immediately call a POISON CENTER or doctor/physician.
P314:
- Get medical attentiodvice if you feel unwell.
- P308+313: IF exposed or concerned: Get medical attentiodvice.
- P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P330:
Rinse mouth.
Ruxolitinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-509)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
