| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 100 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide.
- CAS number: 1393441-53-6
- Molecular formula: C21H27N3O2.
- Purity: >99.5%
- Concentration: 0.1-10 µM.
- Form: Lyophilized powder.
- Solubility: 100 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: KV2 channels
- Source: Synthetic
- Activity: RY796 is a blocker of KV2.2 and KV2.1 channels, with IC50 of 0.09 and 0.25 µM respectively1.
Scientific background
KV channels are voltage-gated potassium channels that open in response to membrane depolarization thus serving as key elements after cell repolarization. KV channels regulate numerous physiological processes. KV2 channels are widely expressed in the CNS, pancreas and smooth muscle.RY796 is a synthetic blocker of the KV2.1 and KV2.2 channels. It has an effective concentration of 0.1-10 µM and an IC50 of 0.09 µM and 0.25 µM for the KV2.1 and KV2.2 channels respectively. RY796 has greater selectivity for KV2 channels over other KV channels out of 1894 compounds in a study conducted by Herrington, J. et al. In addition, RY796 does not affect other ion channels such as sodium and calcium.RY796 blocks the KV channel in a use and dose dependent manner1. In an experiment examining the role of KV channels in the regulation of insulin and somatostatin release from pancreatic islets, RY796 caused an increase of GSIS (glucose stimulated insulin secretion) in vitro however not producing the same effect in live mice. RY796 was also found to increase glucose stimulated somatostatin release from pancreatic δ-cells2.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
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