| Field | Specification |
|---|---|
| Applications | |
| Source | Endogenous metabolite |
| Molecular weight | |
| Molecular formula | C4H9LiO5 |
| Activity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
(S)-3,4-Dihydroxybutyric acid lithium hydrate, a normal human urinary metabolite, is a β-oxidation metabolite of γ-hydroxybutyrate. It can be used for research on succinic semialdehyde dehydrogenase deficiency[1]. It is supplied as a white to off-white solid (C4H9LiO5, MW 144.05).
Physical & Chemical Properties
| Molecular Formula | C4H9LiO5 |
|---|---|
| Molecular Weight | 144.05 g/mol |
| Appearance | Solid |
| Color | White to off-white |
| Structure Classification | Ketones, Aldehydes, Acids |
| SMILES | O=C([O-])C[C@H](O)CO.[Li+].[x].[y].O |
| Signaling Pathway | Metabolic Enzyme/Protease |
| Bioactivity Class | Human Endogenous Metabolite |
| Initial Source | Endogenous metabolite |
| Solubility | In Vitro: H2O: 125 mg/mL (867.75 mM; Requires sonication) |
| Storage | 4°C, sealed storage, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| H2O | 125 mg/mL (867.75 mM) | requires sonication |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture; avoid repeated freeze-thaw cycles.
If water is used as the stock solvent, dilute to the working solution and sterilize it through a 0.22 μm filter before use.
In Vivo
Choose the formulation that suits the animal model and route of administration. Percentages are volume ratios of the final working solution. Prepare the working solution fresh on the day of dosing; if precipitation or phase separation occurs, gentle warming or sonication can help.
Direct preparation of the working solution
These formulations are prepared directly, without a DMSO stock; use them promptly after preparation.
Protocol 1
| Composition | PBS |
|---|---|
| Result | 100 mg/mL (694.20 mM); clear solution; requires sonication |
Data provided by the manufacturer.
In Vitro
Urine from patients with succinic semialdehyde dehydrogenase (SSADH) deficiency contains an increased concentration of excreted (S)-3,4-Dihydroxybutyric acid lithium hydrate[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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