Santacruzamate A

Santacruzamate A is a highly selective histone deacetylase 2 (HDAC2) inhibitor derived from marine cyanobacteria. It has been studied for its neuroprotective effects in Alzheimer’s disease models, where it attenuates amyloid-beta-induced toxicity and enhances endoplasmic reticulum stress tolerance. Its selectivity for HDAC2 over HDAC6 makes it a promising candidate for epigenetic modulation in neurodegenerative disease therapy, with potential applications in memory enhancement and synaptic plasticity.

GHS Hazard Statements:

Not Classified

Santacruzamate A (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-613)

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• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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