| Field | Specification |
|---|---|
| Applications | |
| Molecular weight | |
| Molecular formula | C58H46Na2O8P2 |
| SMILES | |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
SARS-CoV-2-IN-29 disodium is a two-armed diphosphate ester with a benzene-based molecular tweezer system. It shows antiviral activity with IC50 values of 1.5 μM against SARS-CoV-2 and 1.6 μM against spike pseudoparticle transduction, and it induces liposomal membrane disruption with an EC50 of 3.0 μM[1]. Its molecular formula is C58H46Na2O8P2, with a molecular weight of 978.91 g/mol.
Physical & Chemical Properties
| Molecular Formula | C58H46Na2O8P2 |
|---|---|
| Molecular Weight | 978.91 g/mol |
| SMILES | CC(C=C1)=CC=C1COP(OC(C2=C3C4C5=CC(C6CC7C8=C6C=CC=C8)=C7C=C5C2C4)=C(C9C%10=C(C%11C9)C=C%12C(C%13C%14=C(C%12C%13)C=CC=C%14)=C%10)C%11=C3OP(OCC%15=CC=C(C=C%15)C)(O[Na])=O)(O[Na])=O |
| Signaling Pathway | Anti-infection |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 3.0 μM (viral liposome, SARS-CoV-2)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
[1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with your institution's chemical hygiene plan.
In Vitro
SARS-CoV-2-IN-29 (CP024) disodium inhibits SARS-CoV-2 (IC50=1.6 μM) and has low cytotoxicity (Caco2 cells, CC50=77.4 μM)[1]. At 0-15 μM for 2 h, it inactivates SARS-CoV-2 and inhibits infection, with an IC50 value of 1.5 μM[1]. It also suppresses various enveloped viruses, with IC50s of 2.1 μM against influenza A virus (IAV), 2.1 μM against measles virus (MeV), and 1.8 μM against herpes simplex viruses (HSV-1), respectively[1].
Cell Viability Assay[1]
| Cell Line | Caco2 cells exposed with SARS-CoV-2 (2 h, 37 °C) |
|---|---|
| Concentration | 0, 0.23, 0.93, 3.75, 15 μM |
| Incubation Time | 2 hours; determined infection rates on day 2 |
| Result | Inhibited SARS-CoV-2 infection activity to Caco2 cells. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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