SB-366791

SKU:BHB11900110
Suppliers
StressMarq Biosciences Inc.
StressMarq Biosciences Inc.
Details Products
Overview
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SB-366791 is a research-grade small-molecule inhibitor of TRPV1 supporting Neuroscience and Ion Channels research. Supplied as a white solid with >98% purity (CAS 472981-92-3, MW 287.75) Soluble to 10 mM in ethanol and to 100 mM in DMSO; store at -20°C. For research use only.
Cas No. 472981-92-3
Molecular Formula C16H14CINO2
Purity >98%
Application Notes TRPV1 blocker
Options selector
Catalog no. Size
SIH-321-10MG 10 mg
SIH-321-50MG 50 mg
Available Options

Select the variant that best fits your experiment. Availability and lead time may vary by option.

  • Options: Size (2) — 10 mg, 50 mg.
  • Lead time: options listed as “in stock at manufacturer” typically ship in 2-3 business days; other statuses may take longer.
  • Storage: -20ºC
  • Shipping: ships at ambient temperature.
  • Upon receipt: store at the recommended temperature as soon as possible.
  • Sales terms and conditions: Please review prior to ordering.
Field Specification
Mfr No SIH-321
Activity
  • Inhibitor
Alternative Names (2E)-3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide, N-(3-Methoxyphenyl)-4-chlorocinnamide
Cas No. 472981-92-3
Form White solid
Molecular Weight 287.75
Product Type
  • Biochemicals
  • Small Molecules
Purity >98%
Shipping Shipped Ambient
SMILES COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl
Solubility Soluble to 10 mM in ethanol and to 100 mM in DMSO
Source Synthetic
Storage -20ºC

SB-366791 is a potent and selective antagonist of the TRPV1 receptor, which is involved in pain perception and neuroinflammation. By blocking TRPV1 activation by capsaicin, acid, or heat, SB-366791 is used to study nociceptive pathways and inflammatory responses in the nervous system. Its specificity makes it a valuable tool for dissecting TRPV1-mediated mechanisms in neurodegenerative and pain-related disorders.

Classification: Caution: Substance not fully tested yet.

Safety Phrases:

  • S22 - Do not breathe dust
  • S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
  • S24/25- Avoid contact with shin and eyes

SB-366791 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-321)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

  • Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
  • Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
  • Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
  • QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
  • Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).

1. Gunthorpe M.J., et al. (2004) Neuropharmacology. 46(1): 133-149.

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