SB203580

SB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAP kinase, particularly the p38α isoform. It also inhibits phosphorylation of heat shock protein 27 (HSP27) and can activate Raf-1 signaling. In neuroscience, SB203580 is used to study the role of p38 MAPK in neuroinflammation, synaptic plasticity, and neuronal survival. Its high selectivity over kinases such as LCK, GSK-3β, and PKBα makes it a reliable tool for dissecting p38-mediated signaling in neurodegenerative disease models. SB203580 is cell-permeable and is frequently employed in studies of Alzheimer's disease, stroke, and other CNS disorders involving inflammatory and stress responses.

Classification: Acute toxicity, Oral (Category 4), H302

Serious eye damage (Category 1), H318

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H302 Harmful if swallowed.
• H318 Causes serious eye damage.

Precautionary statements:

• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P280 Wear protective gloves/ eye protection/ face protection.
• P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
• P305 + P351 + P338 IF IN EYES: Rinse cautiously wit h water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310 Immediately call a POISON CENTER or doctor/ physician.
• P330 Rinse mouth.
• P501 Dispose of contents/ container to an approved waste disposal plant

SB203580 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-474)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

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