| Field | Specification |
|---|---|
| Target | |
| Alternative names | SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2 |
| Gene ID | |
| Host | |
| Clonality | |
| Isotype | |
| Reactivity | |
| Applications | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310 |
| Conjugate | |
| Concentration | |
| Storage | |
| Catalog no. (Mfr.) | |
| Main SKU |
Scientific Background
domain:The PID domain mediates binding to the TrkA receptor.,function:Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.,miscellaneous:PubMed:15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed:12006576.,PTM:Phosphorylated on tyrosines by the Trk receptors.,similarity:Contains 1 PID domain.,similarity:Contains 1 SH2 domain.,subunit:Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2.,tissue specificity:Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.,
Product Overview
This polyclonal antibody, raised in Rabbit, recognizes Sck. It is validated for Western Blot, Immunohistochemistry.
Validated Applications
| Applications | Western Blot, Immunohistochemistry |
|---|---|
| WB 1 | 500-2000 |
| IHC-p 1 | 50-300 |
Optimal dilutions should be determined by the end user for each application and sample type.
Immunogen
The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310
Specifications
| Host | Rabbit |
|---|---|
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Reactivity | Human, Rat |
| Immunogen | The antiserum was produced against synthesized peptide derived from human SHC2. AA range:261-310 |
| Concentration | 1 mg/mL |
| Observed Band | 59kD |
| Subcellular Location | intracellular,cytosol,plasma membrane, |
| Swiss-Prot | P98077 |
| Gene ID | 25759 |
| Storage | -20°C/1 year |
Reactivity Notes
Validated reactivity: Human, Rat. For other species, epitope conservation may allow cross-reactivity; confirm with appropriate controls.
Safety & Handling
This product is for research use only (RUO) and is not intended for diagnostic or therapeutic use. The formulation contains sodium azide; handle with standard laboratory precautions.
Related Products
Explore related antibodies and reagents for Sck research from ELK Biotechnology, or contact us for alternative formats.
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