| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Concentration | |
| Form | Lyophilized powder. |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Solubility | 150 mM in water. Centrifuge all product preparations before use (10000 x g 5 min). |
| Source | Synthetic |
| Storage | |
| Target |
Product details
- Chemical name: 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.
- CAS number: 153-98-0
- Molecular formula: C10H13ClN2O.
- Purity: >98%
- Concentration: 50 nM - 50 µM.
- Form: Lyophilized powder.
- Solubility: 150 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
- Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
- Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
- Target: 5-HT1, 5-HT2, 5-HT3 receptors
- Source: Synthetic
- Activity: Serotonin is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo1.
Scientific background
Serotonin is the endogenous agonist of 5-HT receptors and the endogenous substrate for the synthesis of a number of molecules, such as melatonin, formyl5hydroxykynurenamine, and 5hydroxyindoleacetic acid.Serotonin (5HT), also known as 5hydroxytryptamine is a monoamine derived from tryptophan. Primarily, serotonin can be found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS)1. Only 2% of serotonin is present in the CNS where it plays an important role in the etiology of many mental disorders. 5-HT also plays an important role in regulating mood and social behavior, appetite, sleep, pain, bone density, tissue regeneration, platelet aggregation, gastrointestinal function, memory and sexual desire and function1,2. In addition, serotonin affects the immune, gastrointestinal and nervous systems in a paracrine, endocrine, and juxtacrine manner2.An extensive use or overdose of serotonergic drugs can lead to a rare life threatening syndrome called serotonin syndrome that includes mental status changes, neuromuscular abnormalities and autonomic hyperactivity3.
Lead time: 1-2 Business Days
Country of origin: Israel/IL
Applications key
Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.
Bioassay tested: Yes
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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