| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide |
| Cas No. | |
| Form | Off-white powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (35 mg/ml) |
| Source | Synthetic |
| Storage |
SGI-1027 is a small-molecule inhibitor of DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B. It interferes with epigenetic regulation by blocking DNA methylation, thereby reactivating silenced genes. In neurodegenerative disease research, SGI-1027 is of interest for its potential to modulate gene expression patterns associated with neuronal survival, synaptic plasticity, and neuroinflammation. Epigenetic dysregulation is a hallmark of several CNS disorders, and DNMT inhibitors like SGI-1027 may offer therapeutic avenues for restoring normal gene function.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
SGI-1027 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-596)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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