| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2,2-dimethylbutanoate |
| Cas No. | |
| Form | White solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble to 75 mM in ethanol and 50 mM in DMSO |
| Source | Synthetic |
| Storage |
Simvastatin is a lipid-lowering agent belonging to the statin class, primarily used to reduce cholesterol levels and prevent cardiovascular disease. In neuroscience, simvastatin has garnered interest for its potential neuroprotective effects. It inhibits HMG-CoA reductase, thereby reducing the synthesis of cholesterol and isoprenoids—molecules involved in protein prenylation and cellular signaling. This mechanism may influence neuroinflammation, oxidative stress, and amyloid-beta accumulation, all of which are implicated in neurodegenerative diseases such as Alzheimer's. Simvastatin's ability to cross the blood-brain barrier further supports its potential as a therapeutic agent in neurological disorders.
Classification: Harmful. May be harmful if inhaled, swallowed, or absorbed through skin.
Safety Phrases:
- S22 - Do not breathe dust
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Risk Phrases:
R62- Possible risk of impaired fertility
Simvastatin (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-257)
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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