| Field | Specification |
|---|---|
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C18H14N4O3S2 |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
Sirt1/2-IN-2 is a dual inhibitor of SIRT1 and SIRT2, with IC50 values of 1.8 μM and 2.4 μM, respectively. It completely blocks p53 deacetylation and increases p53 and α-tubulin acetylation, inducing apoptosis and showing anti-proliferative activity against human leukemia cell lines[1]. It is supplied as a white to off-white solid (C18H14N4O3S2, MW 398.46) at 90% purity.
Physical & Chemical Properties
| CAS Number | 670267-73-9 |
|---|---|
| Molecular Formula | C18H14N4O3S2 |
| Molecular Weight | 398.46 g/mol |
| Purity | 90% |
| Appearance | Solid |
| Color | White to off-white |
| SMILES | O=S(NC1=CC(SC2=NN=CN2)=C(C3=C1C=CC=C3)O)(C4=CC=CC=C4)=O |
| Signaling Pathway | Cell Cycle/DNA Damage; Apoptosis; Epigenetics |
| Storage | Powder: -20°C, 3 years. In solvent: -80°C, 6 months; -20°C, 1 month. |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
IC50: 1.8 μM (SIRT1), 2.4 μM (SIRT2), 65 μM (SIRT3)[1]
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
Sirt1/2-IN-2 (compound hsa55) (5 μM; 48 h) induces apoptosis in several tumor cell types, with IC50 values of 13 μM (MV4-11), 11.5 μM (MOLM-13), 34.4 μM (THP1), and 27.5 μM (Jurkat)[1]. At 100 μM (30 min), Sirt1/2-IN-2 lowers the thermal stability of both SIRT1 and SIRT2 proteins across a range of temperatures, and at 25 μM and 30 μM (24 h) it raises the level of acetylated p53 and α-tubulin in MOLM-13 cells[1].
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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