| Field | Specification |
|---|---|
| Target | |
| CAS no. | |
| Applications | |
| Molecular weight | |
| Molecular formula | C13H15ClN2O |
| Purity | |
| SMILES | |
| Form | Solid |
| Storage | |
| Shipping | |
| Catalog no. (Mfr.) | |
| Main SKU |
Compound Overview
SIRT1-IN-2 is a potent, selective inhibitor of SIRT1 (silent information regulator 1), with an IC50 of 1.6 μM[1]. It is supplied as a white to light yellow solid (C13H15ClN2O, MW 250.72) at 98.31% purity.
Physical & Chemical Properties
| CAS Number | 2470969-89-0 |
|---|---|
| Molecular Formula | C13H15ClN2O |
| Molecular Weight | 250.72 g/mol |
| Purity | 98.31% |
| Appearance | Solid |
| Color | White to light yellow |
| SMILES | CC(C1=C(NC2=CC=C(C=C21)Cl)CC(N)=O)C |
| Target | SIRT1, SIRT2 |
| Signaling Pathway | Cell Cycle/DNA Damage; Epigenetics |
| Solubility | In Vitro: DMSO: 100 mg/mL (398.85 mM; Requires sonication; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) |
| Storage | 4°C, sealed storage, away from moisture and light. In solvent: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). |
| Shipping | Room temperature in continental US; may vary elsewhere. |
Biological Activity
IC50 & Target
|
SIRT1 1.6 μM (IC50) |
SIRT2 39 μM (IC50) |
Literature Cited
Sources cited in this description and in the In Vitro & In Vivo Data tab. Peer-reviewed publications that used this product are listed under References.
Safety
For Research Use Only. Not for use in diagnostic or therapeutic procedures, and not for human or veterinary use. Handle in accordance with the Safety Data Sheet and your institution's chemical hygiene plan.
In Vitro
| Solvent | Solubility | Notes |
|---|---|---|
| DMSO | 100 mg/mL (398.85 mM) | requires sonication; use freshly opened DMSO (absorbed moisture lowers solubility) |
Aliquot the stock solution and store it at -80°C (up to 6 months) or -20°C (up to 1 month); sealed storage, away from moisture and light; avoid repeated freeze-thaw cycles.
Data provided by the manufacturer.
In Vitro
SIRT1-IN-2 (0-100 μM, 48 h) inhibits proliferation of the human cancer cell lines K562, HCT-116, HepG2, A549, and MCF-7, and is significantly less cytotoxic to 293T cells and HUVEC[1].
Cell Cytotoxicity Assay[1]
| Cell Line | Human cancer cell lines (K562, HCT-116, H460, HepG2, A549, HT-29, MCF-7) and normal cell lines (293T, HUVEC). [1] |
|---|---|
| Concentration | 0, 0.01, 0.1, 1, 10, 100 μM |
| Incubation Time | 48 h |
| Result | Inhibited the proliferation of Human cancer cell lines including K562, HCT-116, HepG2, A549, and MCF-7, with IC50 values of 51, 37, 40, 48, and 48 μM, respectively. And showed significantly less cytotoxic on 293T cells and HUVEC, with IC50 values of > 100 and 45 μM, respectively. |
Data provided by the manufacturer. Numbered citations refer to the Literature Cited list in the product description.
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